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README for GRCh37 annotation files
Last updated: November 5, 2019
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The files provided in this directory are symlinks to the latest 
assembly and annotation data available for the human GRCh37 assembly.

The latest version of the GRCh37 assembly is:
assembly name: GRCh37.p13
assembly accession: GCF_000001405.25
URL: https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.25/

The latest genome annotation available is:
assembly: GRCh37.p13
type: interim (current known RefSeqs)
known RefSeqs from: 03-07-2022
model RefSeqs from: none included

files:
GRCh37_latest_genomic.fna.gz
GRCh37_latest_genomic.gff.gz
----------------------------
Files with genomic sequence in FASTA format and annotation in GFF3 format
for the latest annotated version of the GRCh37 assembly.

GRCh37_latest_protein.faa.gz
GRCh37_latest_protein.gpff.gz
GRCh37_latest_rna.fna.gz
GRCh37_latest_rna.gbff.gz
----------------------------
Files corresponding to the set of RefSeq RNA transcripts and proteins
annotated on the latest version of the GRCh37 assembly. Note some RefSeq
transcripts and proteins found in these files may not correspond to the
latest versions available in Entrez due to ongoing curation.

GRCh37_latest_knownrefseq_alignments.bam
GRCh37_latest_knownrefseq_alignments.bam.bai
----------------------------
Files corresponding to alignments of known RefSeq transcripts (NM_* and
NR_* accession prefixes) to the latest annotated version of the GRCh37 assembly.

Additional information about the genome annotation and alignment files 
is available at:
ftp://ftp.ncbi.nlm.nih.gov/genomes/refseq/vertebrate_mammalian/Homo_sapiens/annotation_releases/105.20190906/README_Homo_sapiens_annotation_release_105.20190906


ClinVar annotation files are updated monthly:
FTP: ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf_GRCh37/

The latest dbSNP annotation available is:
build: dbSNP human build 155 (b155)
release date: 05-25-2021
FTP: ftp://ftp.ncbi.nlm.nih.gov/snp/latest_release/VCF/

dbVar annotation files are updated periodically:
FTP: ftp://ftp.ncbi.nlm.nih.gov/pub/dbVar/data/Homo_sapiens/by_assembly/GRCh37/gvf/